RNA binding

Atx2 CPEB4 CRM1 CSTF2 CSTF2T CYCT1 DAZAP1 Dcp1 Dcp2 DDX3X Dhh1 Edc3 elF4GII EWSR1 FIB1 FMRP FUS GAR-1 GNL2 Grb2 hNPM1 hnRNPA0 hnRNPA1 hnRNPA1a hnRNPA1b hnRNPA1L2 hnRNPA2 hnRNPA3 hnRNPAB hnRNPD hnRNPDL hnRNPH1 hnRNPH2 hnRNPH3 HP1a hRPB1 hTIA1 Imp5 Impα Impβ LBR Lsm4 MEX-5 mTIA1 OCT4 p53 Pab1 Pat1 Pbp1 PGL-1 PGL-3 PRMT1 PSPC1 PTB PTP1B Pub1 RARa RNase E rpL23a rpL5 SOX2 SURF6 TAF15 Tau TDP-43 TIAL1 TNPO1 Ubiquitin Whi3 xNPM1

DNA binding

ABL1 AR CBX2 CcmM CYCT1 DDX3X engrailed-2 ER FUS GATA2 GCN4 hGAS HistoneH1 hNPM1 hnRNPA1 hnRNPA1b hnRNPA2 hnRNPD hnRNPDL HP1a hRPB1 LBR MED1 MEX-5 mGAS MYC NANOG OCT4 p53 PIASx PSPC1 RARa scRPB1 Sos1 SOX2 SURF6 TAF15 Tau TDP-43 TIAL1 VRN1 β-amyloid

Protein binding

4EBP2 ABL1 Aquaporin aquaporin-Z AR beta-tubulin BRD4 BuGZ CBHII CBX2 cortactin CRM1 CYCT1 DAXX DDX3X DYRK1A elF4GII ER EWSR1 fibrillin-1 FMRP FtsZ FUS Fyn GATA2 GCN4 gephyrin GKAP Grb2 hHP1α hNPM1 hnRNPA1 hnRNPA1b hnRNPA2 hnRNPD Homer1a Homer1c Homer3 HP1a hRPB1 Imp5 Impα Impβ Intersectin-1 Kap121 LBR LC3b LYZ MED1 MED15 MEX-5 mHP1α Mid1p MYC NCK1 nephrin Numb N-WASP OCT4 p53 p62 pAP PIASx PRMT1 PrP PSD-95 PTP1B RARa rpL23a scSup35 SEPA-1 Shank3 Sos1 SPD-5 spSup35 SYN1 Tau TDP-43 TNPO1 VHL xNPM1 β-amyloid

Enzyme binding

ABL1 AR BRD4 CRM1 CYCT1 DAXX ER Fyn Grb2 hHP1α hNPM1 hnRNPA0 hnRNPD HP1a HP1β hRPB1 Imp5 Impα Impβ LAT LC3b MEX-5 mHP1α NCK1 OCT4 OVA p53 p62 Pab1 PIASx PRMT1 PrP PSD-95 PTP1B RARa rpL5 Sgo SPD-2 SPOP srGAP1 SUMO3 SYN1 Tau TNPO1 TPXL-1 Ubiquitin VHL β-amyloid

Receptor binding

ABL1 AR beta-tubulin ER FUS Fyn gephyrin Grb2 Homer1a Homer1c Homer3 MED1 NCK1 p62 PrP PSD-95 PTP1B RARa Shank3 β-amyloid

Ion binding

ABL1 Af1cbbL Af2cbbL AR beta-tubulin BuGZ Dcp2 ER EWSR1 fibrillin-1 FUS Fyn GATA2 gephyrin hGAS hlyA hRPB1 Impβ Intersectin-1 MEX-5 mGAS OVA p53 p62 PIASx PrP PTP1B RARa RNase E Robo scRPB1 seRbcL Shank3 spSup35 TAF15 β-amyloid

NTP binding

ABL1 beta-tubulin Dbp1 Dcp2 DDX3X Ddx4 Dhh1 DYRK1A FtsZ Fyn gephyrin GNL2 hGAS LAF-1 mGAS Numb p53 PLK-1 RscbbX scSup35 spSup35 SYN1 SYN2

Chromatin binding

AR BRD4 CBX2 CYCT1 Dhh1 ER FMRP FUS GATA2 GCN4 hGAS hHP1α hNPM1 hnRNPD HP1a HP1β hRPB1 MED1 mGAS mHP1α p53 Pab1 Pat1

Enzyme activity

ABL1 Af1cbbL Af1cbbS Af2cbbL Af2cbbS beta-tubulin BRD4 CBHI CBHII CBM CrRbcS CYCT1 Dbp1 Dcp2 DDX3X Ddx4 Dhh1 DYRK1A ER FIB1 FtsZ Fyn gephyrin GNL2 Grb2 hGAS hRPB1 LAF-1 LBR LYZ MED1 mGAS OsRbcS p62 pAP PGL-1 PGL-3 PIASx PLK-1 PRMT1 PTP1B RNase E Robo scRPB1 scSup35 SecbbS seRbcL spSup35 TRX VHL

Transcription factor activity

AR engrailed-2 ER GATA2 GCN4 MYC NANOG OCT4 p53 PSPC1 RARa SOX2 TDP-43

Others

5HT1A ADF3 AK alpha-tubulin bacteriorhodopsin bElastin EGFP EPG-2 EPYC1 FCA Gads GFP gliadins HBP-1 HBP-2 hElastin hγ-D-crystallin MBP mCherry MEG3 Mfp-3S Ncav Not1 Pdc1 Pon RanGTP RBP2 Resilin RIM1α rγ-D-crystallin SlmA SLP-76 SynGAP UBQLN2 γM1 γM4 γM7 γM8b γM8c γM8d