FUS P35637
Full protein nameRNA-binding protein FUS;75 kDa DNA-pairing protein;Oncogene FUS;Oncogene TLS;POMp75;Translocated in liposarcoma protein
Gene nameFUS;TLS
SpeciesHomo sapiens
LocalizationNucleus.
DescriptionFUS (RNA-binding protein FUS), an essential paraspeckle component, has 27 repeats of Y[G/S]QQ or [S/G]Y[S/G] and contains a N terminal PLD and a RRM domain, two RGG-rich domains separated by a zinc finger (ZnF), and a non-canonical PY nuclear localization signal (NLS). The LC domains, includes the N-terminal SYGQ-rich domain and C-terminal three RGG domains enriched in RGG/RG motifs that are extensively modified with asymmetric dimethyl groups by PRMT1 or PRMT8.
The PLDs of FUS family proteins are intrinsically disordered and have low complexity. The PLDs are typically enriched in tyrosine. The RBDs comprise one or more folded RNA recognition modules (RNA recognition motif, RRM), but they also carry regions of significant intrinsic disorder. The intrinsically disordered regions in RBDs are typically enriched in glycine and positively charged residues, such as arginine.
FUS forms liquid compartments at sites of DNA damage and in the cytoplasm upon stress. It is enriched in the nucleus and involved in transcription, DNA repair, and RNA biogenesis.
GO termchromatin binding
DNA binding
estrogen receptor binding
identical protein binding
ionotropic glutamate receptor binding
metal ion binding
myosin V binding
retinoid X receptor binding
RNA binding
thyroid hormone receptor binding
transcription coactivator activity
Full sequence length526
Database linked
OMIM : 137070    FuzDB : FC0097    IDEAL : IID00451    DisProt : DP01102    MobiDB : P35637   
IDR Region
    1 526
LCR Region
    1 526

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Entry IDProtein(s)Protein typeFusionCleavedRepeatMutationPTMSequence lengthProtein structure typeMain componentsNucleic acid
LLPS000016FUSN-----FUS:526aa(1-526)IDR-foldprotein(1)-
LLPS000017FUSN-----FUS:526aa(1-526)IDR-foldprotein(1) + RNANeat1 RNA
LLPS000018FUSN-----FUS:526aa(1-526)IDR-foldprotein(1) + RNARNA
LLPS000019FUSN-----FUS:526aa(1-526)IDR-foldprotein(1) + RNATorula yeast RNA
LLPS000020FUSN-----FUS:526aa(1-526)IDR-foldprotein(1) + RNAtotal Hela cellular RNA
LLPS000021FUSN-----FUS:526aa(1-526)IDR-foldprotein(1) + RNAtotal Hela cellular RNA + Neat1 RNA
LLPS000022FUS_mN-(IDR)---FUS_m:237aa(1-237)IDRprotein(1)-
LLPS000023FUS_mN-(LC)---FUS_m:163aa(1-163)IDRprotein(1)-
LLPS000024FUS_mN-(LC)---FUS_m:214aa(1-214)IDRprotein(1)-
LLPS000025FUS_mN-(LC)--Phos1FUS_m:163aa(1-163)IDRprotein(1)-
LLPS000026FUS_mN-(LC)-M29-FUS_m:163aa(1-163)IDRprotein(1)-
LLPS000027FUS_mN-(NTD)---FUS_m:267aa(1-267)IDRprotein(1)-
LLPS000028FUS_mN-(PLD)---FUS_m:211aa(1-211)IDRprotein(1)-
LLPS000029FUS_mN-(PLD)-M2-FUS_m:211aa(1-211)IDRprotein(1)-
LLPS000030FUS_mN-(PrD)-M4-FUS_m:173aa(1-174)IDRprotein(1)-
LLPS000031FUS_mN-(RGG)---FUS_m:40aa(471-510)IDRprotein(1)-
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